Article
Synergistic effects of the polymorphisms in the PAI-1 and IL-6 genes with smoking in determining their associated risk with coronary artery disease.
Clinical biochemistry - 1 May 2008
Sarecka Beata, Zak Iwona, Krauze Jolanta
Abstract excerpt
OBJECTIVES: To assess the relationship between IL-6 and PAI-1 polymorphisms and coronary artery disease (CAD) and to observe the interactions between these polymorphic variants and smoking in the CAD risk. DESIGN AND METHOD: The study population consisted of 178 patients with angiographically documented CAD and 202 blood donors. The analyses of genetic polymorphisms were performed using the PCR-RFLP method....
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