Article
Certification of reference materials for detection of the human prothrombin gene G20210A sequence variant.
Clinical chemistry and laboratory medicine - 1 Jan 2008
Gancberg David, Corbisier Philippe, Meeus Nele, Marki-Zay Janos, Mannhalter Christine, Schimmel Heinz
Abstract excerpt
BACKGROUND: There is a need for reference materials (RMs) in the field of genetic testing for verification of test results obtained in patients and probands. For the frequent genetic variation G20210A in the prothrombin gene, it has been shown that purified plasmids containing the gene fragment harbouring the mutation constitute good candidate RMs. METHODS: Plasmid-type RMs were characterised for homogeneity,...
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