Article
Mutation analysis of oxisterol-binding-protein gene in patients with age-related macular degeneration.
Genetic testing - 1 Jan 2007
Torrini Margherita, Marchese Cristiana, Vanzetti Mario, Marini Valeria, Origone Paola, Garré Cecilia, Mareni Cristina
Abstract excerpt
Allelic variants of several genes are increasingly recognized as susceptibility factors in age-related macular degeneration (AMD). Because of its metabolic characteristics the macula is sensitive to oxidative damage, and supplementation with antioxidants has been shown to be effective in slowing the progression of disease in AMD patients. The oxisterol-binding-protein (OSBP2) gene is expressed mainly in the...
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