Article
Cyclic AMP-dependent protein kinase controls energy interconversion during the catalytic cycle of the yeast copper-ATPase.
FEBS letters - 19 Mar 2008
Valverde Rafael H F, Morin Isabelle, Lowe Jennifer, Mintz Elisabeth, Cuillel Martine, Vieyra Adalberto
Abstract excerpt
The pathogenesis of human Menkes and Wilson diseases depends on alterations in copper transport. Some reports suggest that intracellular traffic of copper might be regulated by kinase-mediated phosphorylation. However, there is no evidence showing the influence of kinase-related processes in coupled ATP hydrolysis/copper transport cycles. Here, we show that cyclic AMP-dependent protein kinase (PKA) regulates...
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