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Article

A Fra-1-dependent, matrix metalloproteinase driven EGFR activation promotes human lung epithelial cell motility and invasion.

Journal of cellular physiology - 1 Aug 2008

Adiseshaiah Pavan, Vaz Michelle, Machireddy Narsa, Kalvakolanu Dhananjaya V, Reddy Sekhar P

Abstract excerpt

We and others have shown a persistently high induction of Fra-1 transcription factor (a dimeric partner of AP-1) levels by respiratory carcinogens in pulmonary epithelial cells. Fra-1 is frequently overexpressed in various human tumors and cancer cells. We have recently shown that Fra-1 significantly promotes growth, motility, and invasion of human pulmonary epithelial cells, the precise molecular mechanisms by...

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Source

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Identifiers

PMID: 18288638
DOI: 10.1002/jcp.21410
PMCID: PMC2836166

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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