Article
Mesothelial cell transformation requires increased AP-1 binding activity and ERK-dependent Fra-1 expression.
Cancer research - 1 Nov 2002
Ramos-Nino Maria E, Timblin Cynthia R, Mossman Brooke T
Abstract excerpt
Mesothelioma is a unique and insidious tumor associated historically with occupational exposure to asbestos. The transcription factor, activator protein-1 (AP-1) is a major target of asbestos-induced signaling pathways. Here, we demonstrate that asbestos-induced mesothelial cell transformation is linked to increases in AP-1 DNA binding complexes and the AP-1 component, Fra-1. AP-1 binding to DNA was increased...
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