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Article

Analysis of polymorphisms in the 3' untranslated region of the LDL receptor gene and their effect on plasma cholesterol levels and drug response.

International journal of molecular medicine - 1 Mar 2008

Chen Wei, Wang Shukui, Ma Yuling, Zhou Yue, Liu Haiyan, Strnad Pavel, Kraemer Fredric B, Krauss Ronald M, Liu Jingwen

Abstract excerpt

The proximal section of the 3' untranslated region (3'UTR) of LDL receptor (LDLR) mRNA contains important regulatory sequences that control the messenger stability and mediate the cholesterol-lowering drug berberine (BBR)-induced increase in LDLR mRNA half-life. In the present study, we examined whether single nucleotide polymorphisms (SNPs) within this region cause a predisposition to the development of coronary...

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Identifiers

PMID: 18288382

Genes

LDLR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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