Article
RalGDS couples growth factor signaling to Akt activation.
Molecular and cellular biology - 1 May 2008
Hao Yansheng, Wong Richard, Feig Larry A
Abstract excerpt
The Akt kinase is a key regulator of cell proliferation and survival. It is activated in part by PDK1-induced phosphorylation. Here we show that RalGDS, a Ras effector protein that activates Ral GTPases, has a second function that promotes Akt phosphorylation by PDK1 by bringing these two kinases together. In support of this conclusion is our finding that suppression of RalGDS expression in cells inhibits both...
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