Article
Analysis of cis-elements that facilitate extrachromosomal persistence of human papillomavirus genomes.
Virology - 10 May 2008
Pittayakhajonwut Daraporn, Angeletti Peter C
Abstract excerpt
Human papillomaviruses (HPVs) are maintained latently in dividing epithelial cells as nuclear plasmids. Two virally encoded proteins, E1, a helicase, and E2, a transcription factor, are important players in replication and stable plasmid maintenance in host cells. Recent experiments in yeast have demonstrated that viral genomes retain replication and maintenance function independently of E1 and E2 [Angeletti,...
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