Article
Mutation analysis of the MDM4 gene in German breast cancer patients.
BMC cancer - 15 Feb 2008
Reincke Scarlett, Govbakh Lina, Wilhelm Bettina, Jin Haiyan, Bogdanova Natalia, Bremer Michael, Karstens Johann H, Dörk Thilo
Abstract excerpt
BACKGROUND: MDM4 is a negative regulator of p53 and cooperates with MDM2 in the cellular response to DNA damage. It is unknown, however, whether MDM4 gene alterations play some role in the inherited component of breast cancer susceptibility. METHODS: We sequenced the whole MDM4 coding region and flanking untranslated regions in genomic DNA samples obtained from 40 German patients with familial breast cancer....
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