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Article

Lack of association between down syndrome and polymorphisms in dopamine receptor D4 and serotonin transporter genes.

Neurochemical research - 1 Jul 2008

Das Bhowmik Aneek, Dutta Samikshan, Sinha Swagata, Chattopadhyay Anindita, Mukhopadhyay Kanchan

Abstract excerpt

Down Syndrome (DS) patients suffer from cognitive dysfunction, depression, hyperactivity, irritability etc. Dopamine (DA) and serotonin (5HT) are known to control cognitive and behavioral attributes. An increased number of the DA receptor 4 (DRD4) is detected in brain regions primarily involved in cognition. Impairments in executive function have also been reported with depletion in 5HT. A variable number of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18270821
DOI: 10.1007/s11064-007-9581-9

Genes

DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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