Article
Comparative proteomics analysis of vascular smooth muscle cells incubated with S- and R-enantiomers of atenolol using iTRAQ-coupled two-dimensional LC-MS/MS.
Molecular & cellular proteomics : MCP - 1 Jun 2008
Sui Jianjun, Zhang Jianhua, Tan Tuan Lin, Ching Chi Bun, Chen Wei Ning
Abstract excerpt
Atenolol is a beta(1)-selective drug, which exerts greater blocking activity on beta(1)-adrenoreceptors than on beta(2)-adrenoreceptors, with the S-enantiomer being more active than R-enantiomer. The aim of this study was to investigate the proteins with differential protein expression levels in the proteome of vascular smooth muscle cells (A7r5) incubated separately with individual enantiomers of atenolol using...
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