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Article

Single‐dose immunogenicity and protective efficacy of simian adenoviral vectors against <i>Plasmodium berghei</i>

11 Feb 2008

Abstract excerpt

Simian adenoviral vectors (SAd) offer an attractive alternative to standard human adenovirus serotype 5 (AdH5) subunit vaccination, due to pre-existing immunity affecting vaccine performance. We have used a mouse model of liver-stage malaria to test the efficiency of three chimpanzee-origin adenoviral vectors, AdC6, AdC7 and AdC9 containing ME.TRAP as an insert. AdC7 and AdC9 elicited strong immunogenicity (...

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PMID: 18266272
DOI: 10.1002/eji.200737672

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