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Article

Comparison of approaches for machine-learning optimization of neural networks for detecting gene-gene interactions in genetic epidemiology.

Genetic epidemiology - 1 May 2008

Motsinger-Reif Alison A, Dudek Scott M, Hahn Lance W, Ritchie Marylyn D

Abstract excerpt

The detection of genotypes that predict common, complex disease is a challenge for human geneticists. The phenomenon of epistasis, or gene-gene interactions, is particularly problematic for traditional statistical techniques. Additionally, the explosion of genetic information makes exhaustive searches of multilocus combinations computationally infeasible. To address these challenges, neural networks (NN), a...

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PMID: 18265411
DOI: 10.1002/gepi.20307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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