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Article

Rhein reverses the diabetic phenotype of mesangial cells over-expressing the glucose transporter (GLUT1) by inhibiting the hexosamine pathway.

British journal of pharmacology - 1 Apr 2008

Zheng J-M, Zhu J-M, Li L-S, Liu Z-H

Abstract excerpt

BACKGROUND AND PURPOSE: Rhein, an anthraquinone compound isolated from rhubarb, has been proved effective in treatment of experimental diabetic nephropathy (DN). To explore the mechanism of its therapeutic effect on DN, rhein was tested for its effect on the hexosamine pathway. EXPERIMENTAL APPROACH: The influence of rhein on cellular hypertrophy, fibronectin synthesis, glucose uptake, glutamine: fructose...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18264122
DOI: 10.1038/bjp.2008.26
PMCID: PMC2437903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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