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Article

Systems biology of Ewing sarcoma: a network model of EWS-FLI1 effect on proliferation and apoptosis

8 Aug 2013

Abstract excerpt

Ewing sarcoma is the second most frequent pediatric bone tumor. In most of the patients, a chromosomal translocation leads to the expression of the EWS-FLI1 chimeric transcription factor that is the major oncogene in this pathology. Relative genetic simplicity of Ewing sarcoma makes it particularly attractive for studying cancer in a systemic manner. Silencing EWS-FLI1 induces cell cycle alteration and ultimately...

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PMID: 23935076
DOI: 10.1093/nar/gkt678

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