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Article

Superinfection as a driver of genomic diversification in antigenically variant pathogens.

Proceedings of the National Academy of Sciences of the United States of America - 12 Feb 2008

Futse James E, Brayton Kelly A, Dark Michael J, Knowles Donald P, Palmer Guy H

Abstract excerpt

A new pathogen strain can penetrate an immune host population only if it can escape immunity generated against the original strain. This model is best understood with influenza viruses, in which genetic drift creates antigenically distinct strains that can spread through host populations despite the presence of immunity against previous strains. Whether this selection model for new strains applies to complex...

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Identifiers

PMID: 18252822
DOI: 10.1073/pnas.0710333105
PMCID: PMC2538888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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