Article
Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene.
American journal of human genetics - 1 Feb 2008
Kayser Manfred, Liu Fan, Janssens A Cecile J W, Rivadeneira Fernando, Lao Oscar, van Duijn Kate, Vermeulen Mark, Arp Pascal, Jhamai Mila M, van Ijcken Wilfred F J, den Dunnen Johan T, Heath Simon, Zelenika Diana, Despriet Dominiek D G, Klaver Caroline C W, Vingerling Johannes R, de Jong Paulus T V M, Hofman Albert, Aulchenko Yurii S, Uitterlinden Andre G, Oostra Ben A, van Duijn Cornelia M
Abstract excerpt
Human iris color was one of the first traits for which Mendelian segregation was established. To date, the genetics of iris color is still not fully understood and is of interest, particularly in view of forensic applications. In three independent genome-wide association (GWA) studies of a total of 1406 persons and a genome-wide linkage study of 1292 relatives, all from the Netherlands, we found that the 15q13.1...
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