Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotype-phenotype associations and human eye color.

Journal of human genetics - 1 Jan 2011

White Désirée, Rabago-Smith Montserrat

Abstract excerpt

Although eye color is usually modeled as a simple, Mendelian trait, further research and observation has indicated that eye color does not follow the classical paths of inheritance. Eye color phenotypes demonstrate both epistasis and incomplete dominance. Although there are about 16 different genes responsible for eye color, it is mostly attributed to two adjacent genes on chromosome 15, hect domain and RCC1-like...

Topics

Join the communities discussing this publication.

Albinism, Oculocutaneous
Eye Color
HERC2 gene
RCC1 gene
Genetic Association Studies
Guanine Nucleotide Exchange Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Ubiquitin-Protein Ligases

Source

Identifiers

PMID: 20944644
DOI: 10.1038/jhg.2010.126

Genes

HERC2
OCA2
RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotype-phenotype associations and human eye color.PMID 20944644Read ↗

Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene.Semantic proximity Read ↗

Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye colorSemantic proximity Read ↗

Importance of nonsynonymous OCA 2 variants in human eye color predictionSemantic proximity Read ↗

Investigating the genetic architecture of eye colour in a Canadian cohortSemantic proximity Read ↗

Forensic DNA Phenotyping: Genes and Genetic Variants for Eye Color Prediction.Semantic proximity Read ↗

A comparative GWAS of eye colour in light and dark eye genetic backgrounds defined by HERC2 rs12913832 polymorphism in a Canadian cohort of European ancestry.Semantic proximity Read ↗

Gene-gene interactions contribute to eye colour variation in humans.Semantic proximity Read ↗

Eye colour: portals into pigmentation genes and ancestry.Semantic proximity Read ↗

Genome-Wide Association Studies Identify Multiple Genetic Loci Influencing Eyebrow Color Variation in EuropeansSemantic proximity Read ↗

Further insight into the global variability of the OCA2-HERC2 locus for human pigmentation from multiallelic markers.Semantic proximity Read ↗

Gender is a major factor explaining discrepancies in eye colour prediction based on HERC2/OCA2 genotype and the IrisPlex model.Semantic proximity Read ↗

A three-single-nucleotide polymorphism haplotype in intron 1 of OCA2 explains most human eye-color variation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.