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Deadenylation-independent stage-specific mRNA degradation in Leishmania

3 Feb 2008

Abstract excerpt

The life cycle of Leishmania alternates between developmental forms residing within the insect vector (e.g. promastigotes) and the mammalian host (amastigotes). In Leishmania nearly all control of gene expression is post-transcriptional and involves sequences in the 3'-untranslated regions (3'UTRs) of mRNAs. Very little is known as to how these cis-elements regulate RNA turnover and translation rates in...

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PMID: 18250085
DOI: 10.1093/nar/gkn019

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