Osteogenic transcription factor Runx2 is a maternal determinant of dorsoventral patterning in zebrafish.

Abstract excerpt

The maternal genome greatly influences vertebrate embryogenesis before activation of zygotic transcription. Dorsoventral patterning is initiated by maternal factors, but the molecular pathways involved are incompletely understood. In frogs and fish, localized zygotic domains are induced whereby cells either express dorsal or ventral genes. Wnt/beta-catenin signalling promotes expression of the earliest dorsal...

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