In vivo regulation of virulence in Pseudomonas aeruginosa associated with genetic rearrangement.

doi:10.1093/infdis/163.1.143

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Article

In vivo regulation of virulence in Pseudomonas aeruginosa associated with genetic rearrangement.

The Journal of infectious diseases - 1 Jan 1991

Woods D E, Sokol P A, Bryan L E, Storey D G, Mattingly S J, Vogel H J, Ceri H

Abstract excerpt

A chronic pulmonary infection model was used to induce conversion to the mucoid phenotype by Pseudomonas aeruginosa PAO. At 6 months after initial inoculation, organisms isolated from infected lungs demonstrated the mucoid phenotype. Significant decreases (P less than .01) were seen in the levels of exotoxin A, exoenzyme S, phospholipase C, and pyochelin produced by the mucoid P. aeruginosa PAO rat lung isolates...

Topics

Animals
Bacterial Outer Membrane Proteins
Blotting, Southern
Chronic Disease
DNA, Bacterial
Disease Models, Animal
Enzymes
Gene Rearrangement
Ionophores
Iron Chelating Agents
Lipopolysaccharides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lung

Male

Phenotype

Pneumonia

Polysaccharides, Bacterial

Pseudomonas Infections

Pseudomonas aeruginosa

Source

Open in PubMed

Identifiers

PMID: 1824596
DOI: 10.1093/infdis/163.1.143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1824596-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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