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Article

Pseudomonas aeruginosa, mucoidy and the chronic infection phenotype in cystic fibrosis.

Trends in microbiology - 1 Sept 1995

Deretic V, Schurr M J, Yu H

Abstract excerpt

During chronic infections in cystic fibrosis, persistence of Pseudomonas aeruginosa is associated with conversion into forms that are associated with conversion into forms that are characterized by a mucoid colony morphology, rough lipopolysaccharide and, paradoxically, decreased systemic virulence. The mutations underlying these changes occur in global regulators, such as alternative sigma factors and their...

Topics

Bacterial Capsules
Base Sequence
Chronic Disease
Cystic Fibrosis
Genes, Bacterial
Humans
Lung Diseases
Molecular Sequence Data
Mutation
Phenotype
Pseudomonas Infections
Pseudomonas aeruginosa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transformation, Bacterial

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Identifiers

PMID: 8520888
DOI: 10.1016/s0966-842x(00)88974-x

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