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Article

Genetic modification of the schisis phenotype in a mouse model of X-linked retinoschisis.

Genetics - 1 Mar 2008

Johnson Britt A, Aoyama Natsuyo, Friedell Nicole H, Ikeda Sakae, Ikeda Akihiro

Abstract excerpt

X-linked retinoschisis (XLRS) is an inherited form of macular degeneration that is caused by mutations in the retinoschisin (RS1) gene. In addition to macular degeneration, other major characteristics of XLRS include splitting of the retina (schisis) and impaired synaptic transmission as indicated by a reduction in the electroretinogram b-wave. It has been known that patients carrying RS1 mutations show a broad...

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Identifiers

PMID: 18245825
DOI: 10.1534/genetics.107.084905
PMCID: PMC2278062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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