Article
Rescue from oculocutaneous albinism type 4 using medaka slc45a2 cDNA driven by its own promoter.
Genetics - 1 Feb 2008
Fukamachi Shoji, Kinoshita Masato, Tsujimura Taro, Shimada Atsuko, Oda Shoji, Shima Akihiro, Meyer Axel, Kawamura Shoji, Mitani Hiroshi
Abstract excerpt
Patients and vertebrate mutants with oculocutaneous albinism type 4 (OCA4) have mutations in the solute carrier family 45 member 2 (slc45a2) gene. However, there is no empirical evidence for this gene-phenotype relationship. There is a unique OCA4 mutant in medaka (b) that exhibits albinism only in the skin, but the mechanism underlying this phenotype is also unknown. In this study, we rescued medaka OCA4...
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