Article
Association of the brain-derived neurotrophic factor gene and bipolar disorder with early age of onset in mainland China.
Neuroscience letters - 12 Mar 2008
Tang Jihua, Xiao Ling, Shu Chang, Wang Gaohua, Liu Zhongchun, Wang Xiaoping, Wang Huiling, Bai Xueguang
Abstract excerpt
Several evidences have suggested that the brain-derived neurotrophic factor (BDNF) gene may be involved in the pathogenesis of bipolar disorder (BPD), but not all studies get the same result. The paper investigated two genetic polymorphisms of BDNF, C-270T and Val66Met, in a case-control design for their association with BPD. Sixty-seven patients of early age of onset and 130 patients of late age of onset were...
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