Article
Differential control of isocitrate lyase gene transcription by non-fermentable carbon sources in the milk yeast Kluyveromyces lactis.
FEBS letters - 5 Mar 2008
Rodicio Rosaura, López Maria Luz, Cuadrado Sara, Cid Alejandra F, Redruello Begoña, Moreno Fernando, Heinisch Jürgen J, Hegewald Anne-Kathrin, Breunig Karin D
Abstract excerpt
The KlICL1 gene, encoding isocitrate lyase in Kluyveromyces lactis, is essential for ethanol utilization. Deletion analyses identified two functional promoter elements, CSRE-A and CSRE-B. Transcription is activated on ethanol, but not on glucose, glycerol or lactate. Expression depends on the KlCat8p transcription factor and KlSip4p binds to the promoter elements. Glycerol diminishes KlICL1 expression and a...
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