Article
[Hormonal carcinogenesis in women: from mechanisms to prevention].
Comptes rendus biologies - 1 Feb 2008
Rochefort Henri
Abstract excerpt
In spite of the explosion of basic knowledge, breast cancer remains a major problem of public health. Basic endocrinology was at the origin of the first targeted therapy in cancer with the anti-estrogens. Continuous breast cancer cell lines helped to specify the mechanism of the mitogenic activity of estrogens, the basis of their tumour promoter activity. They could not help to explain the deleterious effect of...
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