Application of sensitive and specific molecular methods to uncover global dissemination of the major RDRio Sublineage of the Latin American-Mediterranean Mycobacterium tuberculosis spoligotype family.

doi:10.1128/JCM.02231-07

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Article

Application of sensitive and specific molecular methods to uncover global dissemination of the major RDRio Sublineage of the Latin American-Mediterranean Mycobacterium tuberculosis spoligotype family.

Journal of clinical microbiology - 1 Apr 2008

Gibson Andrea L, Huard Richard C, Gey van Pittius Nicolaas C, Lazzarini Luiz Claudio Oliveira, Driscoll Jeffrey, Kurepina Natalia, Zozio Thierry, Sola Christophe, Spindola Silvana Miranda, Kritski Afrânio L, Fitzgerald Daniel, Kremer Kristin, Mardassi Helmi, Chitale Poonam, Brinkworth Jessica, Garcia de Viedma Dario, Gicquel Brigitte, Pape Jean W, van Soolingen Dick, Kreiswirth Barry N, Warren Robin M, van Helden Paul D, Rastogi Nalin, Suffys Philip N, Lapa e Silva Jose, Ho John L

Abstract excerpt

The Latin American-Mediterranean (LAM) family of Mycobacterium tuberculosis is believed to be the cause of approximately 15% of tuberculosis cases worldwide. Previously, we defined a prevalent sublineage of the LAM family in Brazil by a single characteristic genomic deletion designated RD(Rio). Using the Brazilian strains, we pinpoint an Ag85C(103) single nucleotide polymorphism (SNP) (screened by restriction...

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PMID: 18234868
DOI: 10.1128/JCM.02231-07
PMCID: PMC2292928

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