Article
Tumor microenvironmental genomic alterations in juvenile nasopharyngeal angiofibroma.
Head & neck - 1 Apr 2012
Silveira Sara Martoreli, Custódio Domingues Maria Aparecida, Butugan Ossamu, Brentani Maria Mitzi, Rogatto Silvia Regina
Abstract excerpt
BACKGROUND: To better characterize the pathophysiology of juvenile nasopharyngeal angiofibroma (JNA), endothelial and stromal cells were evaluated by genomic imbalances in association with transcript expression levels of genes mapped on these altered regions. METHODS: High-resolution comparative genomic hybridization (HR-CGH) was used in laser-captured endothelial and stromal cells from 9 JNAs. Ten genes were...
Topics
- Adolescent
- Angiofibroma
- Chromosome Aberrations
- Comparative Genomic Hybridization
- Confidence Intervals
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Genomic Instability
- Humans
- Male
- Nasopharyngeal Neoplasms
- Real-Time Polymerase Chain Reaction
- Sampling Studies