Article
Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in Drosophila.
Nature neuroscience - 1 Mar 2008
Agosto Jose, Choi James C, Parisky Katherine M, Stilwell Geoffrey, Rosbash Michael, Griffith Leslie C
Abstract excerpt
Many lines of evidence indicate that GABA and GABA(A) receptors make important contributions to human sleep regulation. Pharmacological manipulation of these receptors has differential effects on sleep onset and sleep maintenance insomnia. Here we show that sleep is regulated by GABA in Drosophila and that a mutant GABA(A) receptor, Rdl(A302S), specifically decreases sleep latency. The drug carbamazepine (CBZ)...
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