Article
Estimating effects of rare haplotypes on failure time using a penalized Cox proportional hazards regression model.
BMC genetics - 25 Jan 2008
Souverein Olga W, Zwinderman Aeilko H, Jukema J Wouter, Tanck Michael W T
Abstract excerpt
BACKGROUND: This paper describes a likelihood approach to model the relation between failure time and haplotypes in studies with unrelated individuals where haplotype phase is unknown, while dealing with the problem of unstable estimates due to rare haplotypes by considering a penalized log-likelihood. RESULTS: The Cox model presented here incorporates the uncertainty related to the unknown phase of multiple...
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