Immunization with a recombinant fowlpox virus expressing a hepatitis C virus core-E1 polyprotein variant, protects mice and African green monkeys (Chlorocebus aethiops sabaeus) against challenge with a surrogate vaccinia virus.

doi:10.1042/BA20070182

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Immunization with a recombinant fowlpox virus expressing a hepatitis C virus core-E1 polyprotein variant, protects mice and African green monkeys (Chlorocebus aethiops sabaeus) against challenge with a surrogate vaccinia virus.

Biotechnology and applied biochemistry - 1 Oct 2008

Alvarez-Lajonchere Liz, Amador-Cañizares Yalena, Frías Roberto, Milian Yoamel, Musacchio Alexis, Guerra Ivis, Acosta-Rivero Nelson, Martínez Gillian, Castro Jorge, Puentes Pedro, Cosme Karelia, Dueñas-Carrera Santiago

Abstract excerpt

HCV (hepatitis C virus) is a worldwide health problem nowadays. No preventive vaccine is available against this pathogen, and therapeutic treatments currently in use have important drawbacks, including limited efficacy. In the present work a recombinant fowlpox virus, FPCoE1, expressing a truncated HCV core-E1 polyprotein, was generated. FPCoE1 virus generally failed to elicit a humoral immune response against...

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PMID: 18215116
DOI: 10.1042/BA20070182

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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