Article
Ongoing genome reduction in Mycobacterium ulcerans.
Emerging infectious diseases - 1 Jul 2007
Rondini Simona, Käser Michael, Stinear Timothy, Tessier Michel, Mangold Cyrill, Dernick Gregor, Naegeli Martin, Portaels Françoise, Certa Ulrich, Pluschke Gerd
Abstract excerpt
Elucidation of the transmission, epidemiology, and evolution of Mycobacterium ulcerans, the causative agent of Buruli ulcer, is hampered by the striking lack of genetic diversity of this emerging pathogen. However, by using a prototype plasmid-based microarray that covered 10% of the genome, we found multiple genomic DNA deletions among 30 M. ulcerans clinical isolates of diverse geographic origins. Many of the...
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