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Article

Functional genetic variation in aminopeptidase A (ENPEP): lack of clear association with focal and segmental glomerulosclerosis (FSGS).

Gene - 29 Feb 2008

Tonna Stephen, Dandapani Savita V, Uscinski Andrea, Appel Gerald B, Schlöndorff Johannes S, Zhang Kang, Denker Bradley M, Pollak Martin R

Abstract excerpt

The aminopeptidase A (APA) ectopeptidase is an integral membrane-bound zinc metalloprotease that cleaves aspartic and glutamic acidic residues from the N-terminus of a number of protein substrates that includes angiotensin II. Angiotensin II, the most vasoactive component of the renin-angiotensin-aldosterone (RAAS) pathway, can contribute to renal disease by causing an increase in arterial blood pressure leading...

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Source

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Identifiers

PMID: 18206321
DOI: 10.1016/j.gene.2007.11.014
PMCID: PMC2705935

Genes

ENPEP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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