Article
Genetic variation of human aspartic proteinases.
Scandinavian journal of clinical and laboratory investigation. Supplementum - 1 Jan 1992
Taggart R T
Abstract excerpt
The human aspartic proteinases include pepsinogen A, pepsinogen C, cathepsin D, cathepsin E and renin. Comparative analysis of the proteinase genes reveals a high degree of similarity with regard to their respective coding sequences and the location of exon-intron junctions. Despite strong conservation of the regions containing the active site aspartyl groups, genetic polymorphisms have been identified for each...
Topics
- Amino Acid Sequence
- Aspartic Acid Endopeptidases
- Base Sequence
- Cathepsin E
- Cathepsins
- DNA
- Genetic Variation
- Humans
- Molecular Sequence Data
- Pepsinogens
- Renin
