Article
Chromosomal alterations in lymphocytes of patients with Balkan endemic nephropathy and of healthy individuals after incubation in vitro with ochratoxin A.
IARC scientific publications - 1 Jan 1991
Manolov G, Manolova Y, Castegnaro M, Chernozemsky I N
Abstract excerpt
The possible involvement of mycotoxins in chromosomal alterations in patients with Balkan endemic nephropathy (BEN) was investigated cytogenetically. Lymphocyte cultures from patients with BEN and from individuals from a nonendemic region were examined and compared with cultures from healthy people which had been incubated in vitro with noncytotoxic doses of ochratoxin A. Significantly increased numbers of...
Topics
- Balkan Nephropathy
- Chromosome Aberrations
- Female
- Genetic Predisposition to Disease
- Humans
- Lymphocytes
- Male
- Ochratoxins
- X Chromosome