Article
HER-2/neu expression is associated with high tumor cell proliferation and aggressive phenotype in a population based patient series of endometrial carcinomas.
International journal of oncology - 1 Feb 2008
Engelsen Ingeborg B, Stefansson Ingunn M, Beroukhim Rameen, Sellers William R, Meyerson Matthew, Akslen Lars A, Salvesen Helga B
Abstract excerpt
Gene alterations and overexpression of various oncogenes and cell-cycle regulators are important in tumor development. In a population based series of 316 endometrial carcinomas with long and complete follow-up we investigated the distribution of HER-2/neu and EGFR expression and copy number alteration in endometrial cancers. HER-2/ neu, EGFR and Ki-67 expression in curettage and hysterectomy specimens were...
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