Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glioma pathogenesis-related protein 1 exerts tumor suppressor activities through proapoptotic reactive oxygen species-c-Jun-NH2 kinase signaling.

Cancer research - 15 Jan 2008

Li Likun, Abdel Fattah ElMoataz, Cao Guangwen, Ren Chengzhen, Yang Guang, Goltsov Alexei A, Chinault A Craig, Cai Wei-Wen, Timme Terry L, Thompson Timothy C

Abstract excerpt

Glioma pathogenesis-related protein 1 (GLIPR1), a novel p53 target gene, is down-regulated by methylation in prostate cancer and has p53-dependent and -independent proapoptotic activities in tumor cells. These properties suggest an important tumor suppressor role for GLIPR1, yet direct genetic ev...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to HCT116 Cells

Share to JNK Mitogen-Activated Protein Kinases

Share to Neoplasm Proteins

Share to Nerve Tissue Proteins

Share to Reactive Oxygen Species

Source

Identifiers

PMID: 18199537
DOI: 10.1158/0008-5472.CAN-07-2931

Genes

GLIPR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18199537-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glioma pathogenesis-related protein 1 exerts tumor suppressor activities through proapoptotic reactive oxygen species-c-Jun-NH2 kinase signaling.PMID 18199537Read ↗

Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene clusterSemantic proximity Read ↗

GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancerSemantic proximity Read ↗

The Human Glioma-Associated Oncogene Homolog 1 (GLI1) Family of Transcription Factors in Gene Regulation and DiseasesSemantic proximity Read ↗

The tumor suppressor prostate apoptosis response-4 (Par-4) is regulated by mutant IDH1 and kills glioma stem cells.Semantic proximity Read ↗

GANT‐61 and GDC‐0449 induce apoptosis of prostate cancer stem cells through a GLI‐dependent mechanismSemantic proximity Read ↗

Glioma Pathogenesis-Related 1-Like 1 Is Testis Enriched, Dynamically Modified, and Redistributed during Male Germ Cell Maturation and Has a Potential Role in Sperm-Oocyte BindingSemantic proximity Read ↗

Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and ChemoresistanceSemantic proximity Read ↗

Oncogenic potential of truncated-Gli3 via the Gsk3β/Gli3/AR-V7 axis in castration-resistant prostate cancerSemantic proximity Read ↗

The Circadian Gene Per1 Plays an Important Role in Radiation-Induced Apoptosis and DNA Damage in GliomaSemantic proximity Read ↗

Egr1 Signaling in Prostate CancerSemantic proximity Read ↗

Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation.Semantic proximity Read ↗

Activator Protein-1 Transcription Factors Are Associated with Progression and Recurrence of Prostate CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.