Article
The hypocretin neurotransmission system in myotonic dystrophy type 1.
Neurology - 15 Jan 2008
Ciafaloni E, Mignot E, Sansone V, Hilbert J E, Lin L, Lin X, Liu L C, Pigeon W R, Perlis M L, Thornton C A
Abstract excerpt
BACKGROUND: Patients with myotonic dystrophy type 1 (DM1) frequently have symptoms of excessive daytime sleepiness (EDS). Some patients with DM1 show sleep-onset REM, similar to that observed in narcolepsy. Narcolepsy is characterized by impaired hypocretin (Hcrt) neurotransmission. OBJECTIVE: To test for dysregulation of Hcrt neurotransmission in a prospective cohort of patients with DM1. METHODS: Hcrt levels in...
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