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Article

Validation of the ICSD-2 criteria for CSF hypocretin-1 measurements in the diagnosis of narcolepsy in the Danish population.

Sleep - 1 Feb 2010

Knudsen Stine, Jennum Poul J, Alving Jørgen, Sheikh Søren Paludan, Gammeltoft Steen

Abstract excerpt

STUDY OBJECTIVES: The International Classification of Sleep Disorders (ICSD-2) criteria for low CSF hypocretin-1 levels (CSF hcrt-1) still need validation as a diagnostic tool for narcolepsy in different populations because inter-assay variability and different definitions of hypocretin deficiency complicate direct comparisons of study results. DESIGN AND PARTICIPANTS: Interviews, polysomnography, multiple sleep...

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Identifiers

PMID: 20175400
DOI: 10.1093/sleep/33.2.169
PMCID: PMC2817904

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