Article
Amino acids important for DNA recognition by the response regulator OmpR.
The Journal of biological chemistry - 28 Mar 2008
Rhee Jee Eun, Sheng Wanyun, Morgan Leslie K, Nolet Ryan, Liao Xiubei, Kenney Linda J
Abstract excerpt
Response regulators undergo regulated phosphorylation and dephosphorylation at conserved aspartic acid residues in bacterial signal transduction systems. OmpR is a winged helix-turnhelix DNA-binding protein that functions as a global regulator in bacteria and is also important in pathogenesis. A detailed mechanistic picture of how OmpR binds to DNA and activates transcription is lacking. We used NMR spectroscopy...
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