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The Kazal motifs of RECK protein inhibit MMP‐9 secretion and activity and reduce metastasis of lung cancer cells <i>in vitro</i> and <i>in vivo</i>

2 Dec 2008

Abstract excerpt

RECK is a membrane-anchored glycoprotein which may negatively regulate matrix metalloproteinase (MMP) activity to suppress tumor invasion and metastasis. In this study, recombinant proteins corresponding to the residues 285-368 (named as CKM which contained cysteine knot motif), 605-799 (named as K123 which contained three Kazal motifs), 676-799 (named as K23 which contained the last two Kazal motifs) and...

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PMID: 18194466
DOI: 10.1111/j.1582-4934.2008.00215.x

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