Article
CYP3A5 genotype is associated with longer patient survival after kidney transplantation and long-term treatment with cyclosporine.
The pharmacogenomics journal - 1 Dec 2008
Kreutz R, Bolbrinker J, van der Sman-de Beer F, Boeschoten E W, Dekker F W, Kain S, Martus P, Sietmann A, Friedrichs F, Stoll M, Offermann G, Beige J
Abstract excerpt
The CYP3A5*1 allele has been linked to high expression of CYP3A5 and metabolism of cyclosporine. We evaluated the role of CYP3A5*1 for long-term survival in renal transplant patients in a cohort of 399 patients who underwent cadaveric or living donor kidney allograft transplantation. All patients were treated with a similar cyclosporine-based immunosuppressive maintenance therapy protocol. The mean duration of...
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