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Article

SpxA1, a novel transcriptional regulator involved in X‐state (competence) development in Streptococcus pneumoniae

14 Jul 2009

Abstract excerpt

Streptococcus pneumoniae is a naturally transformable human pathogen. Genome and phylogenetic analyses uncovered two Spx-like global transcriptional regulators, SpxA1 and SpxA2, encoded by S. pneumoniae. spxA1 and spxA2 are not essential, but their simultaneous inactivation is lethal. SpxA1 represses transcription of the early competence operon comCDE and thereby negatively regulates the initiation of the X-state...

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PMID: 19627499
DOI: 10.1111/j.1365-2958.2009.06789.x

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