Lessons from CADASIL.

doi:10.1111/j.1749-6632.2002.tb04819.x

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Article

Lessons from CADASIL.

Annals of the New York Academy of Sciences - 1 Nov 2002

Ruchoux Marie-Magdeleine, Brulin Peggy, Brillault Julien, Dehouck Marie-Pierre, Cecchelli Romeo, Bataillard Marc

Abstract excerpt

Vascular dementia (VaD) includes several different vascular mechanisms and changes in the brain. Among VaD, CADASIL is an inherited angiopathy caused by mutations in the Notch3 gene. The pathological hallmark of CADASIL is a granular osmiophilic material deposit (GOM) that is not only found in the brain, but also in the peripheral vascular tree. Consequently, a window into the brain was opened from a strictly...

Topics

Dementia, Multi-Infarct
Humans
Microcirculation
Mutation
Proto-Oncogene Proteins
Receptor, Notch3
Receptors, Cell Surface
Receptors, Notch
Skin

Source

Open in PubMed

Identifiers

PMID: 12480754
DOI: 10.1111/j.1749-6632.2002.tb04819.x

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