Article
Working through a diagnostic challenge: colonic polyposis, Amsterdam criteria, and a mismatch repair mutation.
Familial cancer - 1 Jan 2008
Jasperson Kory W, Blazer Kathleen R, Lowstuter Katrina, Weitzel Jeffrey N
Abstract excerpt
The two most common causes of hereditary colorectal cancer are Lynch syndrome and familial adenomatous polyposis (FAP). The phenotype of Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is differentiated in part from FAP by the lack of profuse colonic polyposis. Here we describe a proband who presented with greater than 50 adenomatous colonic polyps prior to developing cancer of...
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