Article
Genetic predisposition to colorectal cancer: new pieces in the pediatric puzzle.
Journal of pediatric gastroenterology and nutrition - 1 Jul 2006
Durno Carol A, Gallinger Steven
Abstract excerpt
Colorectal cancer is rare in childhood. The 2 best characterized familial syndromes, hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) and familial adenomatous polyposis (FAP), are autosomal dominant inherited disorders. HNPCC is relevant to pediatric gastroenterology practice because children and adolescents with underlying colorectal cancer can have germ-line mutations of mismatch repair genes....
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