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Article

Enhanced excitation-coupled calcium entry in myotubes expressing malignant hyperthermia mutation R163C is attenuated by dantrolene.

Molecular pharmacology - 1 Apr 2008

Cherednichenko Gennady, Ward Chris W, Feng Wei, Cabrales Elaine, Michaelson Luke, Samso Montserrat, López José R, Allen Paul D, Pessah Isaac N

Abstract excerpt

Dantrolene is the drug of choice for the treatment of malignant hyperthermia (MH) and is also useful for treatment of spasticity or muscle spasms associated with several clinical conditions. The current study examines the mechanisms of dantrolene's action on skeletal muscle and shows that one of dantrolene's mechanisms of action is to block excitation-coupled calcium entry (ECCE) in both adult mouse flexor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Ryanodine Receptor Calcium Release Channel

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Source

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Identifiers

PMID: 18171728
DOI: 10.1124/mol.107.043299
PMCID: PMC2735873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Enhanced excitation-coupled calcium entry in myotubes expressing malignant hyperthermia mutation R163C is attenuated by dantrolene.PMID 18171728Read ↗

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