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Article

Noninvasive measurement of protein aggregation by mutant huntingtin fragments or alpha-synuclein in the lens.

The Journal of biological chemistry - 7 Mar 2008

Muchowski Paul J, Ramsden Richard, Nguyen QuangVu, Arnett Ernest E, Greiling Teri M, Anderson Susan K, Clark John I

Abstract excerpt

Many diverse human diseases are associated with protein aggregation in ordered fibrillar structures called amyloid. Amyloid formation may mediate aberrant protein interactions that culminate in neurodegeneration in Alzheimer, Huntington, and Parkinson diseases and in prion encephalopathies. Studies of protein aggregation in the brain are hampered by limitations in imaging techniques and often require invasive...

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Identifiers

PMID: 18167346
DOI: 10.1074/jbc.M709678200
PMCID: PMC2650484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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